Chronic hepatitis B: interferon - monotherapy or combination with nucleoside analogues?
نویسندگان
چکیده
منابع مشابه
Comparison of interferon monotherapy with interferon-lamivudine combination treatment in children with chronic hepatitis B.
AIM To compare interferon monotherapy with combination treatment using interferon and lamivudine in children with chronic hepatitis B. METHODS Data from 65 children who had received either interferon-alpha (5 MU/m2 subcutaneous thrice a week for 6 months; n=35; Group 1) or this dose of interferon-alpha for 6 months with oral lamivudine for one year (4 mg/Kg/day, maximum 100 mg/day; n=30; Grou...
متن کاملPegylated interferon alpha-2b as monotherapy or in combination with ribavirin in chronic hepatitis delta.
Therapy of chronic hepatitis delta with standard interferon therapy has met with limited efficacy. This study was designed to examine the efficacy and safety of peginterferon with or without ribavirin. Thirty-eight serum hepatitis B surface antigen- and HDV RNA-positive patients with alanine aminotransferase (ALT) more than 1.5 times the upper normal limit received peginterferon alpha-2b (1.5 m...
متن کامل[Cost-effectiveness of nucleoside/nucleotide analogues in chronic hepatitis B].
OBJECTIVE To conduct a cost-effectiveness analysis of drug alternatives with rescue therapy in case of relapse due to viral resistance for the treatment of patients with chronic hepatitis B (CHB). METHODS Hypothetical cohort of patients with CHB, HBeAg-negative, without clinical or histological evidence of cirrhosis, detectable HBV DNA, histological diagnosis of the disease, positive serum HB...
متن کاملEntecavir plus adefovir combination treatment for chronic hepatitis B patients after failure of nucleoside/nucleotide analogues.
BACKGROUND The combination of entecavir, a nucleoside analogue, and adefovir, a nucleotide analogue, would be a promising salvage treatment for chronic hepatitis B (CHB) patients who fail nucleoside/nucleotide analogue (NA) regimens. METHODS A total of 89 CHB patients who had failed NA regimens and were treated with entecavir plus adefovir combination for at least 12 months were included. R...
متن کاملAntiviral therapy for chronic hepatitis B: Combination of nucleoside analogs and interferon.
The ideal goal of chronic hepatitis B (CHB) treatment should be suppression of emergence of hepatocellular carcinoma through the disappearance of hepatitis B s antigen (HBsAg) rather than the control of serum hepatitis B virus-DNA level. For this purpose, various types of combination therapies using nucleoside analogs (NAs) and interferon (IFN) have been conducted. The therapeutic effects of co...
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ژورنال
عنوان ژورنال: Liver
سال: 2008
ISSN: 0106-9543
DOI: 10.1111/j.1600-0676.1998.tb00131.x